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Mitochondrial Lon protease is a gatekeeper for proteins newly imported into the …
Elucidation of the molecular mechanisms of anesthesia-induced neurocognitive deficits in the developing brain and a successful development of therapeutic strategy for the dysfunction

  The research group led by Dr. Hiroyoshi Doi, Dr. Taito Matsuda and Dr. Kinichi Nakashima from the Graduate School of Medical Sciences, Kyushu University succeeded to elucidate the mechanisms of anesthesia-induced neurocognitive dysfunction in the developing brain and identify a novel strategy for the prevention and treatment of the deficiency.
  Human epidemiological studies have suggested that repeated exposure to anesthesia during early childhood leads to neurological deficits such as learning disability in their later life. These anesthesia-induced neurological deficiency is a subject of concern and the elucidation of their mechanisms has been a considerable research interest for more than a decade. The research group focused on adult neurogenesis in the hippocampus and found that exposure to midazolam (MDZ) during infancy persistently alters chromatin accessibility and global transcription to reinforce long-lasting NSC dormancy in the mouse hippocampus until adulthood, resulting in reduced neurogenesis and cognitive decline. Furthermore, a simple physical activity, running, could overcome these adverse outcomes by normalizing MDZ-induced transcriptomic alterations. These findings bring us one step closer to elucidating the mechanisms of anesthesia-induced cognitive decline and developing a novel strategy for its treatment.
  This work was published online in “Proceeding of the National Academy of Sciences of the United States of America” on September 13, 2021 at 3:00 PM U.S. EST. This study was supported by JSPS KAKENHI (JP16H06527, JP16K21734, JP18K14820, JP21H02808) and Research Grant for Public Health Science.
Comments from authors:
  Our findings will pave a way to better understanding of anesthesia-induced neurocognitive   deficits and provide a promising therapeutic strategy for its treatment.
For more information about this research
Early-life midazolam exposure persistently changes chromatin accessibility to impair adult hippocampal neurogenesis and cognition.
#Hiroyoshi Doi, #*Taito Matsuda, Atsuhiko Sakai, Shuzo Matsubara, Sumio Hoka, Ken Yamaura, and *Kinichi Nakashima ( #equal 1st authorship, *shared correspondence )
Proc Natl Acad Sci USA, 2021,

【Contact】Kinichi Nakashima, Professor
phone:+81-92-642-6195 FAX:+81-92-642-6561 Mail:kin1(at) *(at)=@

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